ISAI: Book One is a sci-fi American shōnen manga from the creator of The Whole World Blind and Deadly Living.

Written by Marcus Jimenez with art and letters by Heitor Amatsu, edited by Mark O. Stack, character designs by Mike Becker and logo design by JJ Lopez. This 40-page one shot tells the story of three young scientists who are trying to change the world for the better, but when their experiment turns into a catastrophe, they are left with unimaginable grief and unnatural abilities.